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Published on: September 9, 2011
A Valved Expanded Polytetrafluoroethylene Conduit can Acquire Endothelium After Implantation
Sudesh Prabhu1, Srikanth Kasturi1, Sruti Rao1
1Pediatric Cardiac Services, Narayana Institute of Cardiac Sciences, Bengaluru, India.
Abstract:
We demonstrate histopathology, neointimal proliferation, and neo-endothelialization in an explanted valved expanded polytetrafluoroethylene (ePTFE) conduit 40 months postimplantation that was void of calcification and inflammation, confirmed by CD-31 positivity on immunohistochemistry. Grossly, there was no distortion with preserved leaflets and lack of calcification. Good biocompatibility, nonreactivity, and low antigenicity, combined with neointimal and endothelial layer generation within the conduit might explain the low infection rates and minimal thrombogenicity. These findings support the use of handmade, valved ePTFE conduits as an economically viable option as a right ventricle to pulmonary artery conduit.
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