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Comparing Vitamin D Level Between Patients with Psoriasis and Healthy Individuals: A Systematic Review and
Mahmood Moosazadeh1, Giovanni Damiani2,3, Mohammad Khademloo4
1Gastrointestinal Cancer Research Center, Non-communicable Disease Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Journal of Evidence-Based Integrative Medicine
|November 8, 2023
Summary
Psoriasis patients have a significantly higher risk of vitamin D deficiency. This systematic review highlights the need for further research into vitamin D
Area of Science:
- Dermatology
- Endocrinology
- Immunology
Background:
- Psoriasis is a systemic inflammatory condition.
- Vitamin D derivatives are used topically for their anti-inflammatory effects.
- The role of serum vitamin D levels in psoriasis requires further investigation.
Approach:
- A systematic review and meta-analysis was conducted.
- Searched multiple databases for studies on vitamin D and psoriasis.
- Included 19 studies with 1387 psoriasis patients and 6939 controls.
Key Points:
- Psoriasis patients showed a 3.07 times higher odds ratio for low vitamin D levels.
- A significant standardized mean difference of -0.92 was observed for vitamin D in psoriasis patients.
- Psoriatic individuals are at increased risk of vitamin D deficiency.
Conclusions:
- Psoriasis patients have a substantially higher risk of vitamin D deficiency.
- Further interventional studies are essential to confirm the preventive role of vitamin D.
