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Updated: Jul 11, 2025

Synthesis of 1,2-Azaborines and the Preparation of Their Protein Complexes with T4 Lysozyme Mutants
Published on: March 25, 2017
Synthesis and crystal structure of
Philipp J Gliese1,2, Yannik Appiarius1,2, Tarek Scheele3
1University of Bremen, Institute for Organic and Analytical Chemistry, 28359 Bremen, Germany.
Abstract:
The title compound, C24H30BNSi (I), is an asymmetric 1,2,3,6-tetra-hydro-1,2-aza-borinine consisting of a BN-substituted cyclo-hexa-diene analog with a B-anthracenyl substituent. A ring-closing metathesis with subsequent substitution of the obtained BCl 1,2-aza-borinine using anthracenyl lithium yielded the title compound I. The asymmetric unit (Z = 8) belongs to the ortho-rhom-bic space group Pbca and shows an elongated N-C bond compared to previously reported BN-1,4-cyclo-hexa-diene [Abbey et al. (2008 ▸) J. Am. Chem. Soc. 130, 7250-7252]. The primarily contributing surface inter-actions are H⋯H and C⋯H/H⋯C (as elucidated by Hirshfeld surface analysis) which are dominated by van der Waals forces. Moreover, the non-aromatic BN heterocycle and the protecting group exhibit intra- and inter-molecular C-H⋯π inter-actions, respectively, with the anthracenyl substituent.
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