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Development of olanzapine solid dispersion by spray drying technique using screening design for solubility
Leena Patil1, Umakant Verma1, Rahul Rajput1
1University Institute of Chemical Technology, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon-425001, Maharashtra, India.
ADMET & DMPK
|November 8, 2023
Summary
This study enhanced olanzapine (OLZ) solubility using spray-dried solid dispersion. The novel formulation significantly improved drug solubility and dissolution rates for better oral bioavailability.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Olanzapine (OLZ), a psychotropic medication, suffers from poor water solubility, limiting its oral bioavailability.
- Enhanced solubility is crucial for improving the therapeutic efficacy of olanzapine in treating conditions like schizophrenia and bipolar disorder.
Purpose of the Study:
- To develop an oral dosage form that enhances the solubility and dissolution rate of olanzapine.
- To investigate the efficacy of spray-dried solid dispersion for olanzapine formulation.
Main Methods:
- Olanzapine solid dispersion was prepared using a spray drying technique with polyvinylpyrrolidone K-30, mono amino glycyrrhizinate pentahydrate, and silicon dioxide.
- Characterization included X-ray diffraction (X-RD), Differential Scanning Calorimetry (DSC), Fourier transform infrared spectroscopy, solubility, and encapsulation efficiency (EE) studies.
Main Results:
- X-ray diffraction confirmed the amorphous nature of olanzapine within the solid dispersion.
- The prepared solid dispersion exhibited significantly higher solubility (11.51 mg/ml) compared to pure olanzapine (0.983 mg/ml).
- Encapsulation efficiency ranged from 64% to 90%.
Conclusions:
- Spray-dried solid dispersion effectively enhances the solubility and dissolution rate of olanzapine.
- The formulation holds potential for improving oral bioavailability and therapeutic outcomes.
- Plackett-Burman design is valuable for optimizing variables affecting EE and solubility.
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