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COVID-19 in pediatric palliative care patients: Multicenter, retrospective cohort study
Aleksandra Korzeniewska-Eksterowicz1,2, Olga Brzezinska3, Urszula Dryja2
1Pediatric Palliative Care Unit, Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Lodz, Poland.
Insights
COVID-19 in children receiving palliative care often presented mildly, but data is limited. Advance care planning for COVID-19 is crucial for these vulnerable pediatric patients.
Area of Science:
- Pediatric Palliative Care
- Infectious Diseases
- COVID-19 Research
Background:
- Limited data exists on COVID-19's impact on children with life-limiting conditions.
- Previous studies focused on general pediatric COVID-19 risk factors, not palliative care populations.
Purpose of the Study:
- To investigate the clinical course and severity of COVID-19 in pediatric patients receiving palliative care.
- To highlight the need for specific care plans for this population.
Main Methods:
- Retrospective cohort study analyzing medical records of pediatric palliative care patients with confirmed COVID-19.
- Utilized the WHO Clinical Progression Scale to assess disease severity.
- Data collected from seven participating pediatric palliative care centers between January 2020 and April 2022.
Main Results:
- Sixty pediatric patients (mean age 9.8 years) with COVID-19 were analyzed.
- The most common underlying condition was congenital malformations (42%); fever was the most frequent symptom (85%).
- Most cases were mild (73%), with 25% requiring hospitalization and 3% experiencing severe disease or death.
Conclusions:
- COVID-19 in this cohort was predominantly mild, though the small sample size limits definitive conclusions.
- Emphasizes the importance of advance care planning for COVID-19 in pediatric palliative care.
- Further research is necessary to understand the long-term effects of COVID-19 in children with life-limiting conditions.
Background:
Studies have shown the risk factors for COVID-19 severity in children, including comorbidities, but information on the infection course in children with life-limiting conditions is sparse.
Aim:
To describe the effect of COVID-19 on pediatric patients receiving palliative care due to life-limiting conditions.
Design:
We conducted retrospective cohort study. The WHO Clinical Progression Scale was used to measure COVID-19 severity.
Setting/Participants:
Seven of the 24 invited pediatric palliative care centers participated in this study. We analyzed the medical records of children under palliative care with confirmed COVID-19 (January 2020-April 2022).
Results:
Records of 60 patients with COVID-19 aged 0.24 to 21.6 years (mean (SD); 9.8 (6.6)) were collected. The largest group of patients with COVID-19 was children with congenital malformations and chromosomal abnormalities (42%); the most common manifestation was fever (85%). Bacterial coinfection was confirmed in 17 (28%) children. Fifteen (25%) children required hospitalization, including four admitted to the Intensive Care Unit. Mild COVID-19 was identified in 44 (73%) children, moderate in 11 (18%), severe in 3 (5%), and death in 2 (3%). Six of the 20 eligible children were vaccinated against SARS-CoV-2, followed by 16 mothers and fathers.
Conclusion:
In the study population initial presentation of COVID-19 was predominantly a mild; however, the small sample size precluded definitive conclusions. For children under palliative care, we should identify if they have an advance care plan for COVID-19, such as desires for intensive care support. Further studies are needed to define the short and long-term effects of COVID-19 in children with life-limiting conditions.
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