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Ketamine for Traumatic Assault-Induced Depression: A Case Report.
Caitlyn B Coffelt1, Kyle Gibson, Jason VanLandingham
1University of Georgia College of Pharmacy, Athens, Georgia (Dr Coffelt); and Northeast Georgia Medical Center, Gainesville, Georgia (Ms Gibson and Dr VanLandingham).
Summary
Ketamine offers rapid relief for depression following trauma. A single intravenous dose significantly improved mood and achieved remission in a patient experiencing severe depression after assault.
Area of Science:
- Psychiatry
- Pharmacology
- Trauma Medicine
Background:
- Trauma exposure increases risk for depression and PTSD.
- Ketamine is an emerging alternative treatment for depression.
Observation:
- A 68-year-old female developed severe depression post-assault and surgery.
- Initial depression severity indicated by Montgomery-Asberg Depression Rating Scale (MADRS) score of 37.
Findings:
- A single intravenous ketamine dose (0.5 mg/kg) rapidly improved mood.
- MADRS score decreased to 16 within 4 hours, indicating mild depression.
- Depression symptoms remitted within 24 hours, with MADRS score of 4.
Implications:
- Ketamine shows potential as a rapid-acting antidepressant for trauma patients.
- This case highlights ketamine's efficacy in acute depression management.
- Further research into ketamine for trauma-related depression is warranted.
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