Related Experiment Video
Updated: Jul 11, 2025
05:42
Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
Published on: October 25, 2024
1.2K
Selective Venous Sampling Prompting Unilateral Oophorectomy in an Adolescent With PCOS and Markedly Elevated
Kelsee Halpin1, Emily Paprocki1, Paige Eickhoff2
1Division of Pediatric Endocrinology and Diabetes, Children's Mercy Kansas City, Kansas City, Missouri; University of Missouri-Kansas City - School of Medicine, Kansas City, Missouri.
Journal of Pediatric and Adolescent Gynecology
|November 8, 2023
Summary
Severely elevated testosterone in adolescent polycystic ovary syndrome (PCOS) can be managed with selective venous sampling to localize the source. Unilateral oophorectomy can be a therapeutic option for severe PCOS.
Area of Science:
- Endocrinology
- Pediatric Endocrinology
- Reproductive Endocrinology
Background:
- Imaging is recommended for adolescents with suspected polycystic ovary syndrome (PCOS) and high testosterone to rule out neoplasm.
- Selective venous sampling (SVS) is a consideration when imaging is inconclusive.
Observation:
- A case of an adolescent female with PCOS and peak testosterone of 344 ng/dL (11.9 nmol/L) is presented.
- Initial imaging failed to localize a mass, prompting SVS.
Findings:
- SVS identified the right ovary as the source of hyperandrogenism.
- Pathology after laparoscopic right oophorectomy confirmed PCOS and excluded neoplasm.
- The patient experienced rapid and sustained improvement in hyperandrogenism post-surgery.
Implications:
- Marked testosterone elevation can be associated with adolescent PCOS.
- SVS is valuable for localizing severe hyperandrogenism, but unilateral findings do not always indicate neoplasm.
- Unilateral oophorectomy may serve as a therapeutic intervention for severe PCOS cases.
