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Updated: Jul 11, 2025
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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Lipoprotein(a), platelet function and cardiovascular disease.
Harpreet S Bhatia1, Richard C Becker2, Gregor Leibundgut3
1Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla, CA, USA.
Nature Reviews. Cardiology
|November 8, 2023
Summary
Lipoprotein(a) (Lp(a)) may influence cardiovascular disease by affecting platelet function. Research suggests Lp(a) impacts outcomes in revascularization patients and influences benefits from antiplatelet therapy.
Area of Science:
- Cardiovascular Medicine
- Thrombosis and Hemostasis
- Lipid Metabolism
Background:
- Lipoprotein(a) (Lp(a)) is linked to atherothrombosis, potentially via antifibrinolytic effects.
- Genetic studies do not link high Lp(a) to venous thromboembolism risk.
- Lp(a) interactions with platelet receptors suggest a pro-aggregatory role.
Purpose of the Study:
- To re-examine Lp(a)'s role in regulating platelet function.
- To explore the clinical relevance of Lp(a) and platelet function associations in cardiovascular disease.
Main Methods:
- Review of genetic association studies.
- Analysis of ex vivo clotting properties in patients with elevated Lp(a).
- Examination of observational clinical studies on Lp(a) and revascularization outcomes.
- Inclusion of data from the ASPREE trial regarding LPA polymorphisms and ischemic events.
Main Results:
- Elevated Lp(a) is associated with poorer outcomes post-revascularization.
- Patients with high Lp(a) benefit more from prolonged dual antiplatelet therapy.
- A specific LPA polymorphism linked to high Lp(a) was associated with reduced ischemic events in the ASPREE trial without increased bleeding.
Conclusions:
- Lp(a) may play a significant role in platelet function and cardiovascular risk.
- Further research is needed to fully define the clinical implications of Lp(a)'s impact on platelet activity.
- Understanding Lp(a)-platelet interactions could inform future cardiovascular disease prevention and treatment strategies.
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