Research progress on biodegradable polymeric platforms for targeting antibiotics to the bone

Area of Science:

• Biomaterials Science
• Orthopedic Surgery
• Pharmacology

Background:

• Current bone infection treatments rely on high-dose, prolonged systemic or local antibiotic therapy.
• Poly(methyl methacrylate) (PMMA) cement is the clinical standard but is non-biodegradable, necessitating implant removal surgery.
• Biodegradable drug delivery systems offer a less invasive, more compliant alternative with reduced drug toxicity.

Purpose of the Study:

• To review biodegradable polymeric platforms for targeted local antibiotic delivery to bone.
• To explore various biodegradable systems including micro/nanoparticles, scaffolds, and hydrogels.
• To discuss drug release profiles and system functionality for bone infection treatment.

Main Methods:

• Literature review of biodegradable polymeric drug delivery systems for bone infections.
• Analysis of natural and synthetic polymers for antibiotic delivery.
• Examination of micro- and nanoparticles, scaffolds, hydrogels, and multi-delivery systems.
• Discussion of antibiotic release kinetics and penetration into infected tissues.

Main Results:

• Biodegradable polymers demonstrate excellent biocompatibility and sustained antibiotic release.
• Polymeric platforms show high penetrability into infected bone and soft tissue.
• Various biodegradable systems offer targeted local administration, reducing systemic drug exposure and toxicity.

Conclusions:

• Biodegradable polymeric systems represent a promising, less invasive approach for bone infection treatment.
• These systems enhance antibiotic efficacy and patient compliance compared to traditional methods.
• Further research into drug release profiles is crucial for optimizing these advanced delivery platforms.