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Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

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No causal relationship between thyroid function and Parkinson's disease: A bidirectional Mendelian randomization

Youjie Zeng¹, Si Cao¹, Heng Yang²

¹Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|November 8, 2023

Summary

This summary is machine-generated.

This study investigated the causal link between thyroid function and Parkinson's disease (PD) using Mendelian randomization. Findings indicate no causal relationship exists between thyroid disorders and PD development.

Keywords:

Incidence risk Mendelian randomization Parkinson’s disease Thyroid dysfunction

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Area of Science:

Neuroscience
Endocrinology
Genetic Epidemiology

Background:

Parkinson's disease (PD) is a major global neurodegenerative disorder.
Observational studies suggest a link between thyroid function and PD, but causality is unproven.

Purpose of the Study:

To investigate the potential causal relationship between thyroid function and Parkinson's disease using a bidirectional Mendelian randomization approach.

Main Methods:

Bidirectional Mendelian randomization (MR) analysis utilized GWAS data for thyroid function (free thyroxine [FT4], thyroid-stimulating hormone [TSH], hyperthyroidism, hypothyroidism) and PD.
Inverse variance weighted (IVW) method was primary; MR-Egger and weighted median methods were used for robustness.
Sensitivity analyses included Cochrane's Q test for heterogeneity, MR-Egger intercept and MR-PRESSO for pleiotropy, and leave-one-out analysis for result stability.

Main Results:

No evidence of a causal effect of FT4, TSH, hyperthyroidism, or hypothyroidism on PD was found (P > 0.05).
Conversely, PD did not demonstrate a causal impact on FT4, TSH, hyperthyroidism, or hypothyroidism (P > 0.05).
Sensitivity analyses confirmed the absence of significant heterogeneity, horizontal pleiotropy, and demonstrated stable MR results.

Conclusions:

Mendelian randomization analysis does not support a causal association between thyroid function and Parkinson's disease.
The findings suggest that observed correlations are likely not due to direct causation between thyroid status and PD.