Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

89.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
89.0K
Amino Acid Biosynthetic Pathways01:29

Amino Acid Biosynthetic Pathways

17
Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
17
C4 Pathway and CAM01:27

C4 Pathway and CAM

45.6K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
45.6K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

6.4K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.4K
Protein Networks02:26

Protein Networks

2.3K
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GSEA and the coexpression network approach identify novel pathway connections of molecular processes affected in Porto-sinusoidal vascular disease.

PloS one·2026
Same author

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome and decision-making by blocking fibrin in a model of Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same author

A dataset of rare copy number variants associated with neurodevelopmental and neuropsychiatric disorders.

Scientific data·2026
Same author

Ethical Impact Assessment of Sharing Nanosafety Data.

Open research Europe·2026
Same author

Outcomes and future activities of the 'Pan-European network in Lipidomics and EpiLipidomics - EpiLipidNET'.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Genetic regulators of neuronal survival across metabolic environments.

bioRxiv : the preprint server for biology·2026
Same journal

MAPK/ERK signaling regulates H3K9me3 heterochromatin reorganization to confer mesendoderm developmental competence.

Nucleic acids research·2026
Same journal

Antibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus.

Nucleic acids research·2026
Same journal

Dosage compensation defects due to roX RNA loss are rescued by recalibration of X/autosome stoichiometry.

Nucleic acids research·2026
Same journal

RNA G-quadruplexes function as a tunable switch of FUS phase separation.

Nucleic acids research·2026
Same journal

Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice.

Nucleic acids research·2026
Same journal

Transcriptional interference drives intronic polyadenylation at the endogenous H13/Mcts2 locus.

Nucleic acids research·2026
See all related articles
  1. Home
  3. Wikipathways 2024: Next Generation Pathway Database.
  1. Home
  3. Wikipathways 2024: Next Generation Pathway Database.

Related Experiment Video

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

17.7K

WikiPathways 2024: next generation pathway database.

Ayushi Agrawal1, Hasan Balcı2, Kristina Hanspers1

  • 1Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, 94158, USA.

Nucleic Acids Research
|November 9, 2023

View abstract on PubMed

Summary
This summary is machine-generated.

WikiPathways, an open-source biological pathway database, has been restructured to enhance user experience and maintainability. This evolution supports community curation and scientific collaboration through improved functionality and automation.

More Related Videos

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.3K
Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
11:42

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Published on: October 27, 2017

10.9K

Related Experiment Videos

A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

17.7K
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
05:01

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

3.3K
Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish
11:42

Sample Preparation and Analysis of RNASeq-based Gene Expression Data from Zebrafish

Published on: October 27, 2017

10.9K

Area of Science:

  • Bioinformatics
  • Systems Biology
  • Computational Biology

Background:

  • WikiPathways is a vital open-source resource for biological pathway information.
  • Community collaboration and open science are fundamental to its growth and success.
  • The database faces evolving technical challenges inherent in large-scale data curation.

Purpose of the Study:

  • To detail recent advancements in WikiPathways supporting its continued growth and collaboration.
  • To outline the major restructuring undertaken to ensure future stability and maintainability.
  • To highlight improvements in user experience and community engagement functionalities.

Main Methods:

  • Major website redesign and backend restructuring.
  • Implementation of new functionalities to facilitate community input.
  • Leveraging automation for improved database maintainability and curation.

    • Main Results:

    • Enhanced user experience through a redesigned website.
    • Improved stability and maintainability of the biological pathway database.
    • New features enabling greater community participation and input.

    Conclusions:

    • The restructured WikiPathways platform is poised for future growth and sustained community curation.
    • Enhanced technical infrastructure and user-focused design strengthen its role in biological research.
    • Continued commitment to open science principles ensures its value to the scientific community.