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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Multilayer network changes in patients with migraine.

Jinseung Kim1, Dong Ah Lee2, Ho-Joon Lee3

  • 1Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.

Brain and Behavior
|November 9, 2023
PubMed
Summary

Migraine patients exhibit altered brain network structures compared to healthy individuals. These multilayer network changes in the brain may be linked to the underlying causes of migraine headaches.

Keywords:
magnetic resonance imagingmigraineneural network

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Network Science

Background:

  • Migraine is a complex neurological disorder.
  • Understanding the brain's network alterations in migraine is crucial for identifying pathophysiology.

Purpose of the Study:

  • To investigate alterations in the brain's multilayer network in patients with migraine compared to healthy controls.

Main Methods:

  • Enrolled 82 migraine patients and 53 healthy controls.
  • Utilized 3-tesla MRI with T1-weighted and diffusion tensor imaging (DTI).
  • Performed multilayer network analysis using graph theory.

Main Results:

  • Patients with migraine showed significant global differences in multilayer network properties compared to controls.
  • Key metrics like multilayer modularity and average multiplex participation were higher in migraine patients.
  • Conversely, average multilayer clustering coefficient and overlapping strength were lower in migraine patients.

Conclusions:

  • Significant changes in the brain's multilayer network were observed in migraine patients.
  • These findings contribute to understanding migraine pathophysiology and the complex brain network involved.
  • Specific brain regions may play a pivotal role in the pathophysiology of migraine.