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Updated: Jul 11, 2025

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Zinc Levels and Diabetic Foot Ulcers: A Mini Review.

Nikolaos D Karakousis1, Elisavet E Pyrgioti2, Petros N Georgakopoulos3

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|November 9, 2023
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Summary

Serum zinc levels are often low in patients with diabetic foot ulcers (DFUs). While zinc supplementation may aid DFU healing, more research is needed to confirm its benefits.

Keywords:
diabetic foot ulcermineralstype 2 diabetes mellituszinc

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Area of Science:

  • Biochemistry
  • Endocrinology
  • Wound Healing

Background:

  • Diabetic foot ulcers (DFUs) represent a significant complication of diabetes mellitus.
  • Impaired wound healing is a hallmark of diabetes, contributing to DFU development and persistence.
  • Nutritional deficiencies, including zinc, are implicated in compromised healing processes.

Purpose of the Study:

  • To review current literature on serum zinc levels in individuals with diabetic foot ulcers.
  • To evaluate the potential therapeutic role of zinc supplementation in managing diabetic foot ulcers.

Main Methods:

  • Nonsystematic mini-review of existing studies.
  • Analysis of reported serum zinc concentrations in DFU patient cohorts.
  • Examination of evidence regarding oral zinc supplementation and DFU healing outcomes.

Main Results:

  • A consistent finding across studies is the prevalence of low serum zinc levels in subjects with DFUs.
  • Preliminary evidence suggests that oral zinc supplementation may positively influence DFU healing.
  • Current data is insufficient to establish definitive conclusions on zinc's efficacy.

Conclusions:

  • Low serum zinc is frequently observed in patients suffering from diabetic foot ulcers.
  • Zinc supplementation shows promise as an adjunctive therapy for DFU healing.
  • Further rigorous clinical trials are essential to elucidate the definitive role and optimal use of zinc in DFU management.