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The fibroblast growth factor-Klotho axis at molecular level
Fuqiang Sun1, Panpan Liang2, Bo Wang1
1School of Anesthesiology, Weifang Medical University, Shandong Provincial Medicine and Health Key Laboratory of Clinical Anesthesia, Weifang 261053, Shandong, China.
Open Life Sciences
|November 9, 2023
Summary
Klotho protein regulates calcium, phosphorus, and aging. It acts as a co-receptor for fibroblast growth factors (FGFs) and also functions independently as a hormone to maintain homeostasis.
Area of Science:
- Endocrinology
- Molecular Biology
- Gerontology
Background:
- Klotho is a protein with widespread beneficial effects, including regulating mineral metabolism and neuroprotection.
- Fibroblast growth factors (FGFs) interact with cell surface FGF receptors (FGFRs).
- Endocrine FGFs necessitate Klotho as a co-receptor for FGFR signaling.
Purpose of the Study:
- To elucidate the molecular mechanisms underlying Klotho's membrane signaling.
- To review Klotho's role in calcium and phosphorus regulation via the FGF-Klotho axis.
- To explore Klotho's function as a standalone hormone in maintaining cellular homeostasis.
Main Methods:
- This review synthesizes existing research on Klotho's molecular functions.
- Analysis of signaling pathways involving Klotho and FGF receptors.
- Examination of Klotho's interactions with ion channels and transporters.
Main Results:
- Klotho acts as a crucial co-receptor for endocrine FGFs, mediating their effects.
- Soluble Klotho functions as an independent hormone, regulating ion transport and homeostasis.
- The FGF-Klotho axis is central to metabolic and mineral regulation.
Conclusions:
- Klotho plays a multifaceted role in endocrine signaling and cellular homeostasis.
- Understanding Klotho's membrane signaling is key to its physiological functions.
- Klotho's involvement in aging and metabolic regulation highlights its therapeutic potential.
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