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Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Direct Mouse Trauma/Burn Model of Heterotopic Ossification
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Fibrodysplasia ossificans progressiva.

Chané Smit1, André Uys2

  • 1Department of Oral and Maxillofacial Pathology, School of Dentistry University of Pretoria Pretoria South Africa.

Clinical Case Reports
|November 9, 2023
PubMed
Summary

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder causing bone to form in muscles and connective tissues. Early detection of hallux valgus and soft tissue nodules aids diagnosis and monitoring of this debilitating condition.

Keywords:
cone‐beam computed tomographyheterotopic ossification

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Area of Science:

  • Genetics
  • Orthopedics
  • Radiology

Background:

  • Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive heterotopic ossification.
  • It affects skeletal muscles and ligaments, leading to significant morbidity and disability.
  • The estimated prevalence is one in two million individuals.

Observation:

  • This report details the case of an 8-year-old female patient with FOP.
  • The case highlights the characteristic early signs, including hallux valgus and painful soft tissue nodules.
  • Radiographic examinations were performed to document disease progression.

Findings:

  • Early recognition of clinical signs like hallux valgus and soft tissue masses is crucial for timely FOP diagnosis.
  • Radiographic monitoring is essential for assessing the extent and progression of heterotopic ossification.
  • The case illustrates the typical radiological evolution of FOP.

Implications:

  • Prompt diagnosis of FOP enables earlier management and intervention strategies.
  • Understanding the radiological progression aids in predicting disease course and potential complications.
  • This case underscores the importance of recognizing subtle early signs for improved patient outcomes in FOP.