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Related Experiment Video

Updated: Jul 11, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

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APT weighted imaging in diffuse gliomas.

Lucia Nichelli¹, Moritz Zaiss², Stefano Casagranda³

¹Department of Neuroradiology, Sorbonne Université, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Paris, France.

|November 9, 2023

Summary

This summary is machine-generated.

Amide proton transfer-weighted (APTw) imaging is a reliable MRI technique for neuro-oncology. This review highlights its clinical potential for glioma patients and discusses its application in diffuse gliomas.

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Area of Science:

Radiology and Medical Imaging
Neuro-oncology
Molecular MRI

Background:

Amide proton transfer-weighted (APTw) imaging is a non-invasive molecular MRI technique.
APTw metrics have demonstrated reproducibility and reliability over 15 years of research.
Major MRI vendors now offer APTw sequences, indicating growing clinical acceptance.

Purpose of the Study:

To introduce APTw imaging contrast and its clinical potential in neuroradiology, specifically for glioma patients.
To illustrate the utility of APTw imaging before and after tumor therapy.
To discuss common artifacts, limitations, and future directions for APTw imaging in diffuse gliomas.

Main Methods:

Review of pre-clinical experiments and clinical studies on APTw imaging.
Presentation of APTw imaging principles and contrast mechanisms.
Illustration of clinical cases and artifact examples.

Main Results:

APTw imaging metrics are reproducible and reliable.
APTw imaging shows clinical potential for evaluating gliomas.
Understanding artifacts and limitations is crucial for effective application.

Conclusions:

APTw imaging is an emerging technique with significant value in neuro-oncology.
This review aims to familiarize neuroradiologists with APTw imaging for improved diffuse glioma work-up.
Further refinements and understanding of APTw imaging will enhance its clinical utility.