Related Experiment Video
Updated: Jul 11, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
Published on: June 3, 2018
[Assessment of environmental and genetic risk factors for the development of primary open-angle glaucoma]
A N Samoylov1, D Yu Plotnikov1, P A Tumanova1
1Kazan State Medical University, Kazan, Russia.
Abstract:
Primary open-angle glaucoma (POAG) is a multifactorial disease with both environmental and genetic factors involved in its pathogenesis.
Purpose:
The study evaluates the role of a number of environmental and genetic risk factors in the risk of POAG development and builds a prognostic model.
Material And Methods:
The study group included 197 patients aged 44 to 90 years (98 - patients with POAG, 99 - the control group), who were treated in the Republican Clinical Ophthalmological Hospital of the Ministry of Health of the Republic of Tatarstan named after Prof. E.V. Adamyuk.
Results:
Age, family history of the disease, presence of type 2 diabetes mellitus, arterial hypertension were revealed to be associated with an increased risk of POAG development. The polymorphisms of matrix metalloproteinase MMP9 and vitamin D receptor (VDR) genes were shown to influence the development of POAG. The prognostic model considering these factors had high sensitivity and specificity (72.0% and 82.6% respectively).
Conclusion:
The prognostic model based on environmental and genetic factors is important for assessing the risk of POAG and early detection of the disease.
More Related Videos
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Genetic Lingo
Cancer Prevention
Some...

