Related Experiment Video
Updated: Jul 11, 2025
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.5K
[Trigger factors associated with bullous autoimmune dermatoses]
Constantin Lütgerath1, Christian D Sadik2,3, Nina van Beek2
1Klinik für Dermatologie, Allergologie und Venerologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland. constantin.luetgerath@uksh.de.
Dermatologie (Heidelberg, Germany)
|November 9, 2023
Summary
Identifying triggers like infections, UV light, and certain medications is crucial for diagnosing and managing blistering autoimmune dermatoses, including pemphigus and pemphigoid. Early recognition aids in preventing disease relapse.
Area of Science:
- Dermatology
- Immunology
- Autoimmune Diseases
Context:
- Blistering autoimmune dermatoses are rare, heterogeneous conditions.
- Pemphigus involves intraepidermal blistering; pemphigoid involves subepidermal blistering.
- Understanding triggers is key to managing these diseases.
Purpose:
- To review significant trigger factors for bullous autoimmune dermatoses.
- To discuss the role of triggers in disease onset and exacerbation.
Summary:
- Pemphigus vulgaris may be triggered by vaccinations, viral infections, UV light, and radiation.
- Pemphigus foliaceus is particularly linked to UV exposure; drug-induced pemphigus often resembles it.
- Bullous pemphigoid risk increases with age and is associated with certain medications (DPP-4, PD-1/PD-L1 inhibitors) and neurological diseases.
- Mucous membrane pemphigoid may involve mucosal damage, drugs, and neoplasms.
Impact:
- Recognizing triggers facilitates timely diagnosis of blistering autoimmune dermatoses.
- Knowledge of triggers supports the prevention of disease relapse.
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