Adipose-derived stem cells applied to ankle pathologies: a systematic review

Area of Science:

• Orthopedics
• Regenerative Medicine
• Biotechnology

Background:

• Ankle injuries and conditions like osteoarthritis and osteochondral lesions significantly impact patient mobility.
• Adipose-derived mesenchymal stem cells (ADMSCs) are being investigated for their regenerative potential in orthopedic applications.
• Current treatment options may have limitations, driving the search for novel therapeutic approaches.

Conclusions:

• ADMSC injection, particularly using nonenzymatic mechanical isolation, presents a promising and safe treatment for ankle osteochondral lesions and osteoarthritis.
• Despite positive outcomes in the reviewed studies, the current scarcity and low quality of research preclude definitive conclusions.
• Further high-quality clinical trials are necessary to establish the efficacy and long-term outcomes of ADMSC therapy for ankle conditions.