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Temporal Immunomodulation via Wireless Programmed Electric Cues Achieves Optimized Diabetic Bone Regeneration.

Jiwei Sun1,2,3, Danlei Zhao1,2,3, Yifan Wang2,3

  • 1Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

ACS Nano
|November 9, 2023
PubMed
Summary

This study demonstrates wireless ultrasound stimulation to control electric cues for enhanced diabetic bone regeneration. The technology precisely regulates immune cell behavior, mimicking natural healing for improved tissue repair.

Keywords:
diabetic bone defectimproved bone regenerationpiezoelectric membranestemporal immunomodulationwireless electric cues

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Biomaterial-mediated tissue regeneration aims to mimic natural repair processes.
  • Precise control over dynamic cell behaviors within the microenvironment post-implantation is a significant challenge.
  • Diabetic complications often impair natural bone healing processes.

Purpose of the Study:

  • To develop a method for remote, wireless tuning of electric cues for tissue regeneration.
  • To investigate the potential of ultrasound-stimulated electroactive membranes for diabetic bone repair.
  • To achieve temporal regulation of cell behaviors, specifically macrophage polarization, to match natural healing patterns.

Main Methods:

  • Utilized an electroactive piezoelectric membrane capable of generating electric cues.
  • Employed wireless ultrasound stimulation (US) to remotely control the electric output of the membrane.
  • Investigated the effect of US-mediated electric cues on macrophage polarization and related molecular pathways (e.g., AKT2).
  • Assessed the efficacy of the system in promoting diabetic bone regeneration.

Main Results:

  • Successfully demonstrated remote tuning of electric cues via wireless ultrasound stimulation.
  • Achieved temporal regulation of macrophage polarization, aligning with natural healing immunoregulation patterns.
  • Showed that US-mediated macrophage polarization is linked to a controllable decrease in AKT2 expression and phosphorylation.
  • Significantly promoted diabetic bone repair through this controlled biomaterial-based approach.

Conclusions:

  • A strategy for precise biosimulation of temporal regenerative patterns using controllable electric output was established.
  • Intelligent, external field-responsive biomaterials offer a pathway for optimized diabetic tissue regeneration.
  • This work provides insights into bionic design for precision medicine in regenerative applications.