Related Experiment Video
Updated: Jul 17, 2026
07:51
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
1.6K
Does Corneal Topography Using 3-Dimensional Optical Coherence Tomography Suggest Different Subtypes of Terrien
Minna Ruutila1, Per Fagerholm2, Neil Lagali2
1Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Cornea
|November 9, 2023
Summary
Terrien marginal degeneration shows distinct corneal topography patterns, including crab claw, mixed, and arcuate. These patterns correlate with disease progression and specific tomographic features, suggesting potential subtypes.
Area of Science:
- Ophthalmology
- Corneal Imaging
- Optometry
Background:
- Terrien marginal degeneration (TMD) is a rare, progressive peripheral corneal thinning disorder.
- Understanding TMD's topographical characteristics is crucial for diagnosis and management.
Purpose of the Study:
- To analyze corneal topography in Terrien marginal degeneration.
- To correlate topographic patterns with astigmatism, higher-order aberrations, and corneal curvatures.
- To utilize 3-dimensional anterior-segment optical coherence tomography (3D AS-OCT) for detailed analysis.
Main Methods:
- Classified topographic axial power maps of 29 eyes from 15 patients into crab claw (CC), mixed (M), arcuate (A), and normal patterns.
- Compared regular astigmatism, keratometry, higher-order aberrations, corneal thinning, and curvature changes.
- Utilized visual grading for pattern classification and 3D AS-OCT for tomographic analysis.
Main Results:
- Identified 4 CC, 9 M, and 12 A patterns; 1 normal with clinical disease; 3 normal with unilateral disease.
- CC pattern associated with younger age at diagnosis, rapid progression, superior cavities, anterior bulging, and higher posterior aberrations.
- M pattern linked to older age, slower progression, superonasal steepening, and asymmetric bow tie.
- A pattern showed minimal progression, oldest age at diagnosis, and uniform peripheral thinning.
Conclusions:
- Terrien marginal degeneration exhibits distinct topographic patterns (CC, M, A) suggesting disease subtypes.
- These patterns differ in tomographic features and progression rates.
- Patients with CC and M patterns may require more frequent monitoring due to their distinct characteristics.
