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Increased Blood Pressure Variability Over a 16-Year Period Is Associated With Left Ventricular Diastolic Dysfunction

Jae-Hyeong Park1, Soon-Ki Ahn2, Goo-Yeong Cho3

  • 1Department of Cardiology in Internal Medicine, School of Medicine, Chungnam National University, Chungnam National University Hospital, Daejeon, Korea.

American Journal of Hypertension
|November 9, 2023
PubMed

Insights

Increased blood pressure variability is significantly linked to left ventricular diastolic dysfunction (LVDD) in the general population. This finding highlights the importance of monitoring BP variability for LVDD risk.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Diagnostic Imaging

Background:

  • Left ventricular diastolic dysfunction (LVDD) is common in hypertensive individuals.
  • Elevated blood pressure (BP) variability is suspected to contribute to LVDD.
  • The relationship between BP variability and LVDD in the general population is not well-defined.

Purpose of the Study:

  • To investigate the association between long-term blood pressure variability and left ventricular diastolic dysfunction.
  • To evaluate this relationship within a large, population-based cohort.

Main Methods:

  • Analysis of echocardiographic data from 2,578 participants in the Korean Genome and Epidemiology study over 16 years.
  • Assessment of LVDD via echocardiography during follow-up.
  • Quantification of BP variability using mean, standard deviation (SD), and coefficient of variance (CV).

Main Results:

  • Left ventricular diastolic dysfunction (LVDD) was detected in 9.7% of participants (249 individuals).
  • The LVDD group exhibited higher BP variability, including elevated systolic and diastolic BP, and pulse pressure variability (SD and CV).
  • Multivariate analysis confirmed LVDD association with age, female sex, BMI, hypertension, BUN, and increased BP variability metrics.

Conclusions:

  • Increased long-term blood pressure variability is significantly associated with left ventricular diastolic dysfunction.
  • This population-based study confirms a link between BP variability and LVDD, suggesting clinical relevance for monitoring BP fluctuations.
Abstract

Keywords:
blood pressurediastolehypertensionleft ventriclevariability

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