Related Experiment Video
Updated: Jul 11, 2025
08:12
Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
10.2K
Subchronic exposure to PM2.5 induced renal function damage and intestinal microflora changes in rats
1Affiliated Hospital of Jinggangshan University, Ji'an 343000, China; Center for Clinical Medicine Research, Health Science Center, Jinggangshan University, Ji'an 343009, China.
Ecotoxicology and Environmental Safety
|November 9, 2023
Summary
Exposure to fine particulate matter (PM2.5) disrupts gut bacteria, leading to impaired kidney function. This study links PM2.5-induced gut dysbiosis to kidney damage in rats.
Area of Science:
- Environmental Health
- Microbiology
- Nephrology
Background:
- Inhalable particulate matter (PM2.5) exposure is linked to kidney dysfunction.
- The gut microbiome's role in the gut-kidney axis is increasingly recognized.
- Mechanisms linking PM2.5 exposure to gut-kidney axis abnormalities require further investigation.
Purpose of the Study:
- To investigate the impact of concentrated ambient PM2.5 exposure on kidney function and gut microbiota in rats.
- To explore the correlation between renal impairment and changes in intestinal microbiome composition.
Main Methods:
- Sprague-Dawley rats were exposed to filtered air or concentrated PM2.5 for 12 weeks.
- Renal function was assessed through urine flow rate and biochemical markers.
- Fecal microbiota analysis was performed using diversity indices and LEfSe.
Main Results:
- PM2.5 exposure significantly impaired renal function and increased urine flow rate.
- Reduced bacterial richness and diversity (Chao1, Shannon indices) were observed in PM2.5-exposed rats.
- Specific bacterial groups' abundances correlated significantly with markers of renal function and urine flow rate.
Conclusions:
- Subchronic PM2.5 exposure induces intestinal dysbiosis.
- Gut ecological disorders may contribute to PM2.5-induced kidney dysfunction.
