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Area of Science:

  • Immunology
  • Innate Immunity
  • Cellular Reprogramming

Background:

  • Trained immunity provides innate immune cells with long-term functional memory.
  • Physiologically, it enhances pathogen resistance and immunosurveillance.
  • Dysregulation can cause susceptibility to infections/cancer or autoimmune diseases.

Purpose of the Study:

  • To review mechanisms of trained immunity induction.
  • To explore trained immunity as a target for human diseases.
  • To discuss its role in vaccine efficacy and disease treatment.

Main Methods:

  • Review of immunological and molecular mechanisms.
  • Analysis of trained immunity's role in health and disease.
  • Exploration of therapeutic and prophylactic applications.

Main Results:

  • Trained immunity involves functional reprogramming of innate immune cells.
  • Dysregulated trained immunity is linked to infections, cancer, and autoimmune disorders.
  • Trained immunity modulation presents therapeutic opportunities.

Conclusions:

  • Trained immunity is a crucial target for novel prophylactic and therapeutic strategies.
  • Inducing trained immunity can enhance vaccine efficacy.
  • Targeting trained immunity offers potential treatments for cancer and inflammatory disorders.