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Updated: Jul 11, 2025

Strategies for Study of Neuroprotection from Cold-preconditioning
Published on: September 2, 2010
STING signaling in the brain: Molecular threats, signaling activities, and therapeutic challenges
Kun Yang1, Zhen Tang1, Cong Xing1
1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Abstract:
Stimulator of interferon genes (STING) is an innate immune signaling protein critical to infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and integral part of many neurological diseases. Here, we discuss recent advances in STING signaling in the brain. We summarize how molecular threats activate STING signaling in the diseased brain and how STING signaling activities in glial and neuronal cells cause neuropathology. We also review human studies of STING neurobiology and consider therapeutic challenges in targeting STING to treat neurological diseases.
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