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Post covid cerebral phaeohyphomycosis by Rhinocladiella mackenziei: An unusual association

Alay V Khandhar1, Abhijit Warade1, Umang Agrawal2

  • 1P.D. Hinduja National Hospital and Research Center, Mumbai, India; Department of Neurosurgery and Gamma Knife Radiosurgery, P.D. Hinduja National Hospital and Research Center, Mumbai, 400016, India.

Indian Journal of Medical Microbiology
|November 9, 2023
PubMed

Insights

Cerebral phaeohyphomycosis, a rare fungal brain infection, can be fatal. This case highlights challenges in managing Rhinocladiella mackenziei infection post-COVID-19.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Cerebral phaeohyphomycosis (CP) is a severe central nervous system fungal infection.
  • It is caused by fungi in the order Chaetothyriales, including Rhinocladiella mackenziei (RM).
  • CP has a high mortality rate, exceeding 80%.

Observation:

  • A 65-year-old gentleman developed CP.
  • The infection was secondary to RM.
  • The patient had a history of COVID-19.

Findings:

  • The case presented challenges in both medical and surgical management.
  • This highlights the complexity of treating invasive fungal infections in immunocompromised states or post-viral syndromes.

Implications:

  • Further research is needed on managing CP, especially in post-COVID-19 patients.
  • Early diagnosis and multidisciplinary management are crucial for improving outcomes.
  • Understanding the interplay between viral infections and fungal pathogenesis is important.
Keywords:
COVID-19Cerebral phaeohyphomycosisRhinocladiella mackenziei

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