Acquired Ichthyosis Revealing Lymphocytic Colitis.

Area of Science:

• Dermatology
• Gastroenterology
• Internal Medicine

Background:

• Acquired ichthyosis is a rare condition that can be associated with underlying systemic diseases.
• Lymphocytic colitis is an inflammatory bowel disease characterized by chronic watery diarrhea.

Observation:

• A 69-year-old patient presented with acquired ichthyosis and new-onset diarrhea.
• Investigations revealed lymphocytic colitis, vitamin B12 deficiency, mild anemia, and hypoalbuminemia.
• Skin biopsy showed orthokeratotic hyperkeratosis with a thinned granular layer.

Findings:

• The patient was diagnosed with acquired ichthyosis secondary to lymphocytic colitis.
• Treatment with salazopyrin led to significant improvement in both cutaneous xerosis and diarrhea.

Implications:

• This case underscores the importance of investigating systemic causes for acquired ichthyosis.
• It suggests a potential link between lymphocytic colitis and dermatological manifestations like ichthyosis.
• Salazopyrin may be an effective treatment option for this specific ichthyosis-gastrointestinal disorder association.