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Updated: Jul 11, 2025

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
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Shaping microbiome function with a human milk-oligosaccharide synbiotic.

Ethel Closa1, Loudon Herold1, Matthew T Sorbara1

  • 1Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.

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|November 9, 2023
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Summary
This summary is machine-generated.

Human milk oligosaccharides support Bifidobacterium infantis growth, aiding microbiome recovery after antibiotics. This research highlights synbiotics for developing live biotherapeutic products.

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Area of Science:

  • Microbiology
  • Human Nutrition
  • Gastroenterology

Background:

  • Human milk oligosaccharides (HMOs) are complex carbohydrates found in breast milk.
  • Certain bacteria, like Bifidobacterium infantis, can utilize HMOs as a specific nutrient source.
  • Antibiotic treatments can disrupt the gut microbiome, leading to dysbiosis.

Purpose of the Study:

  • To investigate how HMOs create a niche for Bifidobacterium infantis colonization.
  • To evaluate the effect of Bifidobacterium infantis on gut microbiome recovery post-antibiotic exposure.
  • To explore the potential of synbiotics in developing live biotherapeutic products.

Main Methods:

  • Utilized a tunable system to study the interaction between HMOs and Bifidobacterium infantis.
  • Administered Bifidobacterium infantis to assess its impact on microbiome restoration after antibiotic treatment.
  • Analyzed microbiome composition and function to determine the effects of the intervention.

Main Results:

  • Demonstrated that HMOs establish a nutrient niche supporting reversible Bifidobacterium infantis colonization.
  • Showcased the positive influence of Bifidobacterium infantis on microbiome recovery following antibiotic therapy.
  • Confirmed the viability of using synbiotics for therapeutic purposes.

Conclusions:

  • HMOs play a crucial role in shaping the infant gut microbiome by selectively supporting beneficial bacteria.
  • Bifidobacterium infantis can be a key player in restoring gut homeostasis after antibiotic-induced disruption.
  • Synbiotics represent a promising strategy for the development of effective live biotherapeutic products for gut health.