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Regulation of the Unfolded Protein Response

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...

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Related Experiment Video

Updated: Jul 11, 2025

Assessing Insulin Clearance in Mice via In Situ Liver Perfusion

Assessing Insulin Clearance in Mice via In Situ Liver Perfusion

Published on: December 13, 2024

Author Correction: Disordered metabolism in mice lacking irisin

Yunyao Luo^1,2,3,4, Xiaoyong Qiao^1,2,3,4, Yaxian Ma^1,2,3,4

¹Reproductive Endocrinology and Regulation Laboratory West China Second University Hospital, Sichuan University, #20 Section 3, Ren Min Nan Road, Chengdu, 610041, Sichuan, People's Republic of China.

Scientific Reports

|November 9, 2023

Summary

No abstract available in PubMed .

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