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Advances in immune checkpoint-based immunotherapies for multiple sclerosis: rationale and practice
Amin Daei Sorkhabi1, Erfan Komijani2, Aila Sarkesh1
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Communication and Signaling : CCS
|November 10, 2023
Summary
Immune checkpoint inhibitors show promise for treating multiple sclerosis (MS) by restoring immune balance. Strategies focus on modulating inhibitory and stimulatory checkpoints to combat MS-related neurodegeneration.
Area of Science:
- Immunology
- Neuroimmunology
- Oncoimmunology
Background:
- Immune checkpoint inhibitors (ICPs) are effective in cancer therapy.
- Dysregulated ICPs are implicated in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
- ICPs regulate immune tolerance and balance stimulatory/inhibitory pathways.
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