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Large Variations in Resistance to Degradation between Hyaluronic Acid Viscosupplements: A Comparative Rheological
Guillaume Darsy1,2, Jeremy Patarin1,2, Thierry Conrozier3
1Rheonova, Gières, France.
Cartilage
|November 10, 2023
Summary
Hyaluronic acid (HA) viscosupplements show varied resistance to degradation. Cross-linked HA and those with mannitol offer superior stability, suggesting longer effectiveness in osteoarthritis treatment.
Area of Science:
- Biomaterials Science
- Rheology
- Osteoarthritis Treatment
Background:
- Intra-articular hyaluronic acid (HA) injections are common for osteoarthritis.
- Product effectiveness varies, potentially due to differences in HA half-life and degradation resistance.
Purpose of the Study:
- To compare the degradation resistance of linear and cross-linked hyaluronic acid (HA) viscosupplements.
- To simulate intra-articular mechanical and oxidative stresses using a rheological model.
Main Methods:
- Rheological properties of 8 HA products were measured using a stress-imposed Rheometer.
- Mechanical and oxidative stresses (H2O2 exposure) were applied.
- Changes in complex modulus (G*) and phase tangent (tan δ) were analyzed.
Main Results:
- Significant variations in G* decrease were observed during mixing (-6.4% to -31.3%).
- Low-molecular-weight HA showed greater degradation than medium MW and cross-linked products.
- After oxidative stress, G* varied from -10.1% to -46.3%, with cross-linked HA and mannitol-containing products showing the best resistance.
Conclusions:
- Viscosupplements exhibit substantial differences in degradation resistance.
- The findings highlight the need for clinical studies to compare the duration of effectiveness of various HA products.
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