Related Experiment Video For early development, process
Updated: Jul 11, 2025

Using Primary Neurosphere Cultures to Study Primary Cilia
Published on: April 14, 2017
EMT and primary ciliogenesis: For better or worse in sickness and in health
Camille E Tessier1, Aurore M M Dupuy1, Thomas Pelé1
1Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France.
Abstract:
Epithelial-mesenchymal transition (EMT) and primary ciliogenesis are two cell-biological programs that are essential for development of multicellular organisms and whose abnormal regulation results in many diseases (i.e., developmental anomalies and cancers). Emerging studies suggest an intricate interplay between these two processes. Here, we discuss physiological and pathological contexts in which their interconnections promote normal development or disease progression. We describe underlying molecular mechanisms of the interplay and EMT/ciliary signaling axes that influence EMT-related processes (i.e., stemness, motility and invasion). Understanding the molecular and cellular mechanisms of the relationship between EMT and primary ciliogenesis may provide new insights in the etiology of diseases related to EMT and cilia dysfunction.
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