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Updated: Jul 11, 2025

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination.

Raj N Sewduth1,2, Paolo Carai3, Tonci Ivanisevic1,2

  • 1VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 10, 2023
PubMed
Summary

Blood flow shear stress affects endothelial cells. Non-degradative ubiquitination of GTPases, like RAP1, by WWP2 regulates endothelial function and barrier integrity, impacting vascular health.

Keywords:
GTPaseendothelial cellsmechanobiologyspatial OMICsubiquitin system

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