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Co-infection of Chlamydia psittaci and Tropheryma whipplei: A case report
1Respiratory and Critical Care Discipline, Clinical Medicine College, Affiliated Hospital of Chengdu University, Chengdu 610000, Sichuan Province, China.
Background:
The co-infection of Chlamydia psittaci (C. psittaci) and Tropheryma whipplei (T. whipplei) is unusual, and the detection of pathogenic microorganisms is particularly important for patients with severe diseases or poor experience in treatment. Early identification of pathogens can significantly improve the prognosis of the patients. Targeted next-generation sequencing (tNGS) is currently widely used in clinical practice for various infectious diseases, including respiratory infections, to achieve early, accurate, and rapid microbial diagnosis.
Case Summary:
We report a case of a 40-year-old female patient with a history of contact with parrots who was diagnosed with C. psittaci and T. whipplei infection through bronchial lavage fluid targeted next generation sequencing. After moxifloxacin treatment, the patient's symptoms improved significantly, and the imaging changes were obviously resolved.
Conclusion:
Coinfection with C. psittaci and T. whipplei is not common. In this case, timely and accurate identification of both pathogens was achieved using tNGS. Moreover, the efficacy of monotherapy with moxifloxacin was confirmed.
Insights
A rare co-infection of Chlamydia psittaci and Tropheryma whipplei was diagnosed using targeted next-generation sequencing (tNGS). This early detection and moxifloxacin treatment led to significant patient recovery.
Area of Science:
- Infectious Diseases
- Microbiology
- Genomics
Background:
- Co-infection with Chlamydia psittaci (C. psittaci) and Tropheryma whipplei (T. whipplei) is uncommon.
- Accurate pathogen identification is crucial for managing severe or treatment-resistant infections.
- Targeted next-generation sequencing (tNGS) offers rapid and precise microbial diagnosis for various infectious diseases.
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