Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

D-aspartate in human brain.

E H Man, G H Fisher, I L Payan

    Journal of Neurochemistry
    |February 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease.

    Journal of the neurological sciences·2017
    Same author

    [Unexpected hemorrhage complications in association with celecoxib. Spontaneously reported case series after perioperative pain treatment in gynecological operations].

    Der Anaesthesist·2014
    Same author

    Intranasally-administered deferoxamine mitigates toxicity of 6-OHDA in a rat model of Parkinson׳s disease.

    Brain research·2014
    Same author

    Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice.

    Experimental brain research·2012
    Same author

    Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis.

    Neuroscience·2008
    Same author

    Delivery of interferon-beta to the monkey nervous system following intranasal administration.

    Neuroscience·2008
    Same journal

    The Golgi as a Microtubule Organiser in Neurons.

    Journal of neurochemistry·2026
    Same journal

    A PARK9 iPSC-Derived Dopaminergic Neuron Model Enables Drug Screening Targeting Autophagy-Lysosome Pathway Dysfunction in Parkinson's Disease.

    Journal of neurochemistry·2026
    Same journal

    Opposing Estrous Cycle-Dependent Norepinephrine and Dopamine Regulation in Response to Methamphetamine.

    Journal of neurochemistry·2026
    Same journal

    Exercise Snacking in Alzheimer's Disease: A Mechanistic Rationale Based on Repeated Exerkine Signaling.

    Journal of neurochemistry·2026
    Same journal

    The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex.

    Journal of neurochemistry·2026
    Same journal

    Splice Type-Specific Effects of Gαo Subunits on Cerebellar Anatomy and Synapse Formation.

    Journal of neurochemistry·2026
    See all related articles

    D-aspartate, an uncommon amino acid, increases in human brain white matter during early adulthood and stabilizes in middle age. Its levels in gray matter remain low, with no significant differences observed in Alzheimer

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Aging Research

    Background:

    • D-aspartic acid (D-aspartate) is a biologically uncommon amino acid found in human brain white matter.
    • Previous studies reported its presence, prompting further investigation into its distribution and age-related changes.

    Purpose of the Study:

    • To quantify D/L-aspartate ratios in a larger cohort of normal human brains across different age groups.
    • To investigate the presence and levels of D-aspartate in both white and gray matter throughout the human lifespan.
    • To compare D/L-aspartate ratios in pathological brain conditions (e.g., Alzheimer's disease) with normal aging.

    Main Methods:

    • Analysis of D/L-aspartate ratios in post-mortem brain tissue from 67 normal individuals.
    • Comparison of D-aspartate levels in white matter versus gray matter.

    Related Experiment Videos

  • Assessment of D-aspartate content across various age ranges, from infancy to older adulthood.
  • Evaluation of D/L-aspartate ratios in brains affected by Alzheimer's disease and other pathologies.

    • Main Results:

    • D-aspartate content in white matter shows a rapid increase from age 1 to approximately 35 years, followed by stabilization and a slight decrease in older age.
    • Gray matter consistently exhibits lower D-aspartate levels (approximately half of white matter) throughout the lifespan.
    • No significant differences in D/L-aspartate ratios were detected between normal brains and those with Alzheimer's disease or other pathologies, within current analytical limitations.

    Conclusions:

    • The age-dependent accumulation of D-aspartate in white matter suggests a role in brain aging processes.
    • While not directly linked to Alzheimer's disease in this study, elevated D-aspartate may contribute to age-related protein configuration changes and potential brain dysfunction.
    • Further research is warranted to elucidate the functional implications of D-aspartate accumulation in the aging brain.