Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk factors for severe burn-related injuries among children and youth: a systematic review and meta-analysis.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2026
Same author

Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder.

Human genetics·2026
Same author

Normative modeling for quantitative brain MRI phenotyping and biomarker discovery for pediatric leukodystrophies.

medRxiv : the preprint server for health sciences·2026
Same author

Enrichment of fetal cell-free DNA in early miscarriages for detection of aneuploidy: a novel approach.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

Determinants of severe fall-related injuries among children and youth: a systematic review and meta-analysis.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2026
Same author

Association of Advanced Access With Primary Care Performance: A Systematic Review.

Annals of family medicine·2026
Same journal

From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians.

Clinical chemistry·2026
Same journal

Interlaboratory Comparison of a Glucagon and Oxyntomodulin Immuno-LC-MS/MS Assay: Implications for Diabetes Research.

Clinical chemistry·2026
Same journal

Comparison of Information-Dependent Acquisition and Sequential Window Acquisition of All Theoretical Mass Spectra for Untargeted Drug Testing on a Linear Ion Trap-Pulsing Quadrupole-Time of Flight Mass Spectrometer.

Clinical chemistry·2026
Same journal

Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes.

Clinical chemistry·2026
Same journal

TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations.

Clinical chemistry·2026
Same journal

Rapid Detection of Hemoglobinopathy Variants Using One-Step Library Preparation and Nanopore Sequencing.

Clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: Jul 11, 2025

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

842

Mining the Gap: Deriving Pregnancy Reference Intervals for Hematology Parameters Using Clinical Datasets.

Vilte E Barakauskas1,2, Mary Kathryn Bohn3, Emma Branch4

  • 1Department of Pathology and Laboratory Medicine, BC Children's and Women's Hospital, Vancouver, BC, Canada.

Clinical Chemistry
|November 10, 2023
PubMed
Summary
This summary is machine-generated.

Establishing accurate reference intervals (RIs) for complete blood count (CBC) during pregnancy is crucial. This study developed new pregnancy-specific CBC RIs for Canadian mothers using linked laboratory and registry data, highlighting limitations of traditional trimester-based assessments.

More Related Videos

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics
09:05

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Published on: June 29, 2020

5.2K
Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

501

Related Experiment Videos

Last Updated: Jul 11, 2025

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

842
Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics
09:05

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Published on: June 29, 2020

5.2K
Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

501

Area of Science:

  • Obstetrics and Gynecology
  • Clinical Pathology
  • Medical Informatics

Background:

  • Physiological changes in pregnancy necessitate pregnancy-specific reference intervals (RIs) for laboratory tests, as general population RIs are invalid.
  • Existing studies establishing RIs for pregnant populations are limited, particularly for contemporary Canadian mothers.
  • Retrospective derivation of pregnancy RIs is challenging due to lack of readily available pregnancy and health status data in laboratory information systems (LIS).

Purpose of the Study:

  • To derive retrospective pregnancy-specific reference intervals (RIs) for complete blood count (CBC) and differential tests.
  • To assess the impact of maternal and pregnancy characteristics on CBC laboratory values.
  • To evaluate the suitability of traditional trimester-based RIs versus gestational age-based RIs for pregnant individuals.

Main Methods:

  • A retrospective cohort study utilizing linked data from the British Columbia Perinatal Data Registry and two laboratories.
  • Definition of a 5-year healthy pregnancy cohort (n=143,106 unique term singleton pregnancies).
  • Calculation of CBC and differential RIs using direct and indirect approaches, analyzed by trimester and gestational week.

Main Results:

  • Over 972,000 CBC results were analyzed, with RIs calculated by trimester and gestational week.
  • Observed result trends aligned with existing literature, but specific RI limits differed for many tests.
  • Trimester-specific bins were found to be potentially inappropriate for rapidly changing CBC parameters like red blood cells, leukocytes, and platelets.

Conclusions:

  • Linking comprehensive clinical databases with LIS data offers a robust method for deriving pregnancy RIs.
  • Conventional trimester bins have limitations for defining normal CBC values during pregnancy.
  • The study supports the use of gestational age or empirically derived bins for more accurate CBC reference values in pregnancy.