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Updated: Jul 11, 2025

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π-Extension of Indoles Using Acrolein Linker: Synthesis of Indolo[3,2-a]carbazole-6-carbaldehydes and Racemosin B
Yinghua Li1, Jiang Jin1, Weibin Fan1
1State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
Abstract:
A simple method for the synthesis of indolo[3,2-a]carbazole-6-carbaldehydes by the π-extension of indoles with acrolein is reported. The scope of the method is demonstrated with 33 examples. The products exhibit high activities toward advanced synthesis and are proved to be able to produce valuable chemicals, such as natural products, dyes, and organic fluorescent materials. In addition, the alkaloid racemosin B can be prepared by this method in two steps in ∼50% overall yield.
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