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Pediatric chronic kidney disease: blood cell count indexes as inflammation markers

Aislander Junio da Silva1, Ana Cristina Dos Santos Lopes1, Ana Paula Lucas Mota1

  • 1Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte, MG, Brazil.

Jornal Brasileiro De Nefrologia
|November 10, 2023
PubMed

Insights

Blood cell count indexes like Lymphocyte-Monocyte Ratio (LMR) and Systemic Inflammation Response Index (SIRI) show potential for evaluating inflammation in pediatric chronic kidney disease (CKD). These markers correlate with CKD causes and disease stage.

Area of Science:

  • Pediatric Nephrology
  • Inflammatory Biomarkers
  • Hematology

Background:

  • Chronic kidney disease (CKD) in children often stems from congenital anomalies of the kidneys and urinary tract (CAKUT) and glomerulopathies.
  • Inflammation complicates the diagnosis and staging of pediatric CKD, necessitating research into novel biomarkers.

Purpose of the Study:

  • To evaluate blood cell count-derived indexes as potential biomarkers for pediatric CKD.
  • To determine the association between these indexes and the etiology and staging of pediatric CKD.

Main Methods:

  • Calculated six blood cell count indexes: Neutrophil-Lymphocyte Ratio (NLR), Derived Neutrophil-Lymphocyte Ratio (dNLR), Lymphocyte-Monocyte Ratio (LMR), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), and Systemic Immune-Inflammation Index (SII).
  • Compared indexes between 52 pediatric CKD patients (categorized by etiology and stage) and 33 healthy controls.

Main Results:

  • Lower Lymphocyte-Monocyte Ratio (LMR) was observed in pediatric CKD patients with glomerulopathies (stages 3-4) and CAKUT (stages 3-4) compared to healthy controls.
  • Increased Systemic Inflammation Response Index (SIRI) was found in pediatric CKD patients with other etiologies (stages 3-4) compared to healthy controls.
  • No significant differences were found for other evaluated indexes between groups.

Conclusions:

  • The Lymphocyte-Monocyte Ratio (LMR) and Systemic Inflammation Response Index (SIRI) demonstrate potential as indicators of inflammation in pediatric CKD.
  • These indexes may aid in evaluating CKD etiology and, particularly, disease staging in children.
Abstract

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