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MICROCIRCULATORY ALTERATIONS IN STABLE CORONARY ARTERY DISEASE PATIENTS WITH CONCOMITANT COVID-19

Vasyl Z Netiazhenko1, Serhii I Mostovyi2, Olga M Safonova3

  • 1BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE; STATE INSTITUTION OF SCIENCE «RESEARCH AND PRACTICAL CENTER OF PREVENTIVE AND CLINICAL MEDICINE» STATE ADMINISTRATIVE DEPARTMENT, KYIV, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|November 10, 2023
PubMed

Insights

Stable coronary artery disease patients with COVID-19 show significant microcirculation changes, including capillary remodeling and reduced blood flow velocity. This highlights the impact of COVID-19 on vascular health in SCAD patients.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Microcirculation Research

Background:

  • Stable coronary artery disease (SCAD) is a prevalent condition affecting millions globally.
  • COVID-19 has been associated with various cardiovascular complications.
  • The impact of concomitant COVID-19 on the microcirculation of SCAD patients remains incompletely understood.

Purpose of the Study:

  • To investigate and characterize the alterations in microcirculation among patients with stable coronary artery disease (SCAD) who also have COVID-19.
  • To compare microcirculatory parameters between SCAD patients with and without COVID-19, and with COVID-19 patients without SCAD.

Main Methods:

  • A cross-sectional study involving 80 patients categorized into four groups: SCAD without COVID-19, SCAD with COVID-19, COVID-19 without SCAD, and healthy controls.
  • Microcirculation was assessed using nailfold videocapillaroscopy (NVC) and laser Doppler flowmetry (LDF).

Main Results:

  • Patients with SCAD and COVID-19 (G2) exhibited capillary bed remodeling and significantly reduced capillary blood flow velocity compared to other groups.
  • Laser Doppler flowmetry revealed impaired endothelium-dependent and -independent microvascular regulation in G2.
  • A high prevalence (72%) of microcirculatory hemodynamic "congestion-stasis" (MHCS) or mixed types with reduced microvascular reactivity (MVR) was observed in G2.

Conclusions:

  • The microcirculatory profile in SCAD patients with COVID-19 is characterized by MHCS or mixed types with reduced MVR.
  • A hyporeactive microcirculatory profile was significantly more frequent in SCAD patients with COVID-19 compared to those without.
  • Concomitant COVID-19 significantly impacts microvascular function in patients with stable coronary artery disease.
Abstract

Keywords:
COVID-19SARS-CoV-2 infectionmicrocirculationmyocardial ischemia

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