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Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

378
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
378
Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

193
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
193

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Related Experiment Video

Updated: Jul 11, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
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Seizures at stroke onset: A case-control study.

Ji-Won Kim1, Henning R Stetefeld1, Gereon R Fink2

  • 1Department of Neurology, Faculty of Medicine, University of Cologne, and University Hospital Cologne, Kerpener Strasse, 62, Cologne 50937, Germany.

Seizure
|November 10, 2023
PubMed
Summary
This summary is machine-generated.

Seizures at onset (SaO) are rare in stroke patients but indicate more severe strokes. While SaO did not affect acute stroke therapy rates, it was linked to higher mortality and stroke severity.

Keywords:
Acute symptomatic seizureIschemic strokeLarge vessel occlusionSaOSeizure at stroke onsetrt-PA

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Area of Science:

  • Neurology
  • Stroke Medicine
  • Epileptology

Background:

  • Seizures at onset (SaO) present diagnostic and therapeutic challenges in stroke management.
  • Understanding the clinical implications of SaO is crucial for optimizing patient care.

Purpose of the Study:

  • To investigate the clinical characteristics and management of stroke patients experiencing seizures at onset (SaO).
  • To compare outcomes of SaO patients with stroke patients without SaO.

Main Methods:

  • Retrospective analysis of stroke patients with and without SaO admitted to a tertiary stroke center in Germany (2019-2020).
  • Comparison of SaO patients receiving acute stroke therapies (rt-PA, thrombectomy) with matched controls.
  • Assessment of clinical parameters including stroke type, seizure semiology, NIHSS, mRS, and in-hospital mortality.

Main Results:

  • SaO occurred in 2.3% of stroke patients, predominantly focal to bilateral tonic-clonic seizures.
  • SaO was associated with hemorrhagic strokes and higher in-hospital mortality.
  • SaO patients receiving acute therapy showed higher NIHSS and mRS scores and longer door-to-needle times, but similar outcomes after adjustment.

Conclusions:

  • Seizures at onset are infrequent but signify more extensive strokes.
  • SaO is linked to increased stroke severity and mortality, though acute therapy rates and outcomes are comparable after adjustment for confounders.