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Effects of prenatal single and mixed bisphenol exposure on bone mineral density in preschool children: A

Jun Liang1, Lixiang Pang2, Chunxiu Yang3

  • 1Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.

Ecotoxicology and Environmental Safety
|November 11, 2023
PubMed

Insights

Prenatal exposure to bisphenols impacts bone mineral density (BMD) in preschoolers, with effects varying by chemical and child

Area of Science:

  • Environmental Health
  • Pediatric Bone Health
  • Endocrinology

Background:

  • Bisphenol exposure is linked to bone density changes in adults.
  • The impact of prenatal bisphenol exposure on preschooler bone health is largely unknown.
  • Bisphenols are endocrine-disrupting chemicals found in many consumer products.

Purpose of the Study:

  • To investigate the association between prenatal exposure to single and multiple bisphenols and bone health in preschool children.
  • To explore sex-specific effects of prenatal bisphenol exposure on bone mineral density (BMD).

Main Methods:

  • Study included 230 mother-child pairs.
  • Statistical analyses included generalized linear regression, restricted cubic spline (RCS), principal component analysis (PCA), and Bayesian kernel machine regression (BKMR).
  • Bisphenol levels in maternal samples were measured and correlated with child BMD metrics.

Main Results:

  • Tetrabromobisphenol A exposure was associated with decreased speed of sound in girls.
  • Bisphenol S (BPS) exposure was linked to lower BMD Z scores and increased low BMD (BMDL) risk in boys.
  • Bisphenol A (BPA) exposure showed a protective effect against BMDL in girls, while bisphenol B (BPB) exhibited a U-shaped association with BMDL in girls.
  • Complex, non-monotonic, and sex-specific relationships were observed between bisphenol mixtures and BMDL in girls.

Conclusions:

  • Prenatal exposure to various bisphenols, both individually and as mixtures, can adversely affect bone mineral density in preschool children.
  • The effects are non-monotonic and exhibit significant sex-specific differences.
  • These findings highlight the potential risks of early-life bisphenol exposure to skeletal development.

Keywords:
BisphenolBone mineral densityPregnant womenPreschool children

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