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Oncologic and Fertility Outcomes After Simple Trachelectomy in Women With Early Cervical Cancer
Kathrin Siegler1, Andrea Plaikner1, Hermann Hertel2
1Department of Gynecology (Drs. Siegler, Plaikner, and Köhler).
Study Objective:
This study aimed to present our case series of patients with early-stage cervical cancer undergoing simple trachelectomy (ST). Currently, radical trachelectomy is considered the most appropriate fertility-preserving procedure for the treatment of early-stage cervical cancer. However, there is increasing debate on the appropriate radicality of the surgery to preserve oncologic safety.
Design:
Descriptive retrospective analysis of patient records and evaluation of questionnaires.
Setting:
2 gynecologic oncologic centers, surgeries performed by one surgical team.
Patients:
36 women with early-stage cervical cancer undergoing ST.
Interventions:
Laparoscopic assisted simple vaginal trachelectomy.
Measurements:
Demographic, histologic, fertility, and follow-up data of all patients who underwent ST between April 2007 and July 2021 were prospectively recorded and retrospectively analyzed.
Main Results:
A total of 36 women (mean age: 28 years) underwent ST of whom 81% were nulliparous. Indications for ST were multifocal International Federation of Gynecology and Obstetrics stage IA1 (n = 30), stage IA1 L1 (n = 1), stage IA2 (n = 2), and stage IB1 (n = 3). Mandatory staging procedure was laparoscopic pelvic lymphadenectomy, including bilateral sentinel biopsy in 92% of the cases and systematic in 8%. Residual tumor was histologically confirmed in 8 specimens (22%); 18 women (50%) were seeking parenthood, and 13 succeeded (72%). There were 16 live births, all on term, with a median fetal weight of 3110 grams (2330-4420). One patient had a medical abortion owing to fetal congenital malformation. One pregnancy is ongoing. After a median follow-up of 91.5 months (9-174), all women are alive with no evidence of disease.
Conclusion:
ST represents a de-escalation compared with radical trachelectomy and provides excellent oncologic results with an outstanding fertility rate and obstetric outcome for patients with early cervical cancer. However, clear indications for this tailored fertility-preserving surgery have to be defined in well-designed trials.
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