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Vaccine value profile for leishmaniasis.

Paul M Kaye1, Greg Matlashewski2, Sakshi Mohan3

  • 1York Biomedical Research Institute, Hull York Medical School, University of York, York, UK.

Vaccine
|November 11, 2023
PubMed
Summary
This summary is machine-generated.

Leishmaniasis vaccines are crucial due to the disease's global impact and high mortality, especially in children. A Vaccine Value Profile assesses the potential value of these vital vaccines.

Keywords:
LeishmaniasisVaccinationVaccine value profileVaccines

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Area of Science:

  • Tropical medicine
  • Vaccinology
  • Global health

Background:

  • Leishmaniasis is a global threat, affecting 98 countries and putting 600 million to 1 billion people at risk.
  • Visceral leishmaniasis causes nearly 20,000 deaths annually, disproportionately affecting children under five.
  • Leishmaniasis is a significant Neglected Tropical Disease (NTD) due to its high mortality and morbidity.

Purpose of the Study:

  • To provide a comprehensive assessment of the potential public health, economic, and societal value of leishmaniasis vaccines.
  • To inform stakeholders about the current state of knowledge and identify gaps in leishmaniasis vaccine development.
  • To support the development and licensure of new leishmaniasis vaccines.

Main Methods:

  • Development of a Vaccine Value Profile (VVP) for leishmaniasis.
  • Utilized a working group of subject matter experts from diverse fields.
  • Information gathered from existing, publicly available data.

Main Results:

  • The VVP offers a high-level assessment of leishmaniasis vaccine value.
  • Identified an existing diverse portfolio of manufacturers in endemic countries interested in vaccine development.
  • Highlighted the imperative for leishmaniasis vaccine development due to increasing disease burden, climate change, urbanization, and drug resistance.

Conclusions:

  • There is a clear need for leishmaniasis vaccines to address the significant global health burden.
  • New tools for understanding correlates of protection and assessing vaccine efficacy are advancing vaccine development.
  • The development of a leishmaniasis VVP is a critical step in evaluating and realizing the potential value of these vaccines.