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Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

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Published on: February 24, 2012

An on-demand bioresorbable neurostimulator.

Dong-Min Lee^1,2, Minki Kang³, Inah Hyun^1,2

¹Department of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of Korea.

Nature Communications

|November 11, 2023

Summary

This study introduces an on-demand bioresorbable neurostimulator for peripheral neuropathy treatment. Ultrasound powers the device and enables its rapid, safe elimination, overcoming limitations of current bioelectronic implants.

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Area of Science:

Biomedical Engineering
Materials Science
Neuroscience

Background:

Bioresorbable bioelectronics offer atraumatic removal but face challenges in sustainable powering and predictable device longevity.
Current bioelectronic implants require surgical extraction, posing risks and increasing healthcare costs.
Degradation kinetics of biodegradable polymers complicate the functional lifespan of bioresorbable devices.

Purpose of the Study:

To develop an on-demand bioresorbable neurostimulator addressing limitations of current bioelectronic medical devices.
To enable ultrasound-mediated control over device function and elimination for enhanced clinical applicability.
To provide a reliable and safe therapeutic solution for peripheral nerve conditions.

Main Methods:

Development of an ultrasound-driven triboelectric system for transcutaneous powering of the bioresorbable neurostimulator.
Implementation of a transient mechanism for on-demand, high-intensity ultrasound-induced device degradation.
Neurophysiological assessments to evaluate the therapeutic efficacy of the device in preclinical models.

Main Results:

Demonstrated successful electrical stimulation via ultrasound-driven triboelectricity.
Achieved rapid and safe device elimination using high-intensity ultrasound without adverse effects.
Confirmed therapeutic benefits for compression peripheral nerve injury and hereditary peripheral neuropathy models.

Conclusions:

The on-demand bioresorbable neurostimulator offers a promising solution for peripheral neuropathy treatment.
Ultrasound-mediated control provides a novel approach for managing bioelectronic implant function and removal.
This technology has the potential to advance the development of next-generation medical implants for neurological disorders.