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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
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Protease detection in the biosensor era: A review.

Pratika Rai1, Sabrina N Hoba2, Celine Buchmann1

  • 1Faculty of Computer Sciences and Microsystems Technology, Kaiserslautern University of Applied Sciences, Amerikastr.1, 66482, Zweibrücken, Germany.

Biosensors & Bioelectronics
|November 12, 2023
PubMed
Summary

Protease biosensors offer efficient detection of disease biomarkers. This review compares optical and electrochemical methods for designing versatile protease biosensors, aiding research and point-of-care applications.

Keywords:
BiosensorsElectrochemical biosensorsOptical biosensorsPeptidesProteasesTransducers

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Last Updated: Jul 11, 2025

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Biochemistry

Background:

  • Proteases are implicated as biomarkers in diseases like cancer and cardiovascular conditions.
  • Protease dysregulation affects extracellular matrix and basement membrane.
  • Traditional detection assays lack efficiency compared to modern biosensors.

Purpose of the Study:

  • To review optical and electrochemical detection methods for protease biosensors.
  • To analyze and compare transducer techniques for protease biosensing platforms.
  • To discuss the impact of nanomaterials on biosensor performance.

Main Methods:

  • Review of existing literature on protease biosensors.
  • Analysis of activity-based biosensors utilizing peptide biorecognition elements.
  • Comparison of various transducer techniques (optical and electrochemical).

Main Results:

  • Optical and electrochemical methods offer efficient protease detection.
  • Activity-based biosensors with peptide elements are a key focus.
  • Nanomaterials can enhance biosensor performance.

Conclusions:

  • This review aids in selecting appropriate biosensor designs for protease detection.
  • Protease biosensors show promise for improved disease understanding and point-of-care testing.
  • Further development of protease biosensors can advance diagnostic capabilities.