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Cannabidiol - Help and hype in targeting mucosal diseases
Md Moniruzzaman1, Taskeen Iqbal Janjua2, Jennifer H Martin3
1School of Pharmacy, The University of Queensland, Woolloongabba, QLD 4102, Australia; Inflammatory Bowel Disease Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Cannabidiol (CBD) shows promise for gut and lung diseases, but formulation challenges limit effectiveness. Advanced delivery systems could enhance therapeutic outcomes for these conditions.
Area of Science:
- Pharmacology
- Gastroenterology
- Pulmonology
Background:
- Cannabidiol (CBD) is a non-psychoactive phytocannabinoid with diverse therapeutic potential.
- CBD shows promise for drug-resistant epilepsies, anxiety, pain, and inflammatory disorders.
- Regulatory status of CBD is evolving due to increased usage and emerging safety data.
Purpose of the Study:
- To review the therapeutic potential of CBD in gastrointestinal and lung diseases.
- To identify research gaps and obstacles in CBD-based therapeutic development.
- To explore novel delivery methods for improving CBD efficacy.
Main Methods:
- Review of in vitro, in vivo, and clinical research on CBD for gut and lung diseases.
- Analysis of physicochemical properties and formulation challenges.
- Examination of advanced delivery technologies.
Main Results:
- CBD demonstrates potential in vitro for alleviating gut and lung diseases.
- Physicochemical properties of CBD present significant barriers to in vivo and clinical efficacy.
- Novel formulations and delivery methods are crucial for overcoming these limitations.
Conclusions:
- CBD holds therapeutic promise for gastrointestinal and lung diseases.
- Improving CBD formulation and delivery is essential for clinical success.
- Further research into advanced delivery systems is warranted.
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