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Updated: Jul 11, 2025
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A Complete Pipeline for Isolating and Sequencing MicroRNAs, and Analyzing Them Using Open Source Tools
Published on: August 21, 2019
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EVLncRNAs 3.0: an updated comprehensive database for manually curated functional long non-coding RNAs validated by
Bailing Zhou1, Baohua Ji1,2, Congcong Shen1
1Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China.
Nucleic Acids Research
|November 12, 2023
Summary
The EVLncRNAs database now includes over 25,000 publications, significantly expanding its collection of experimentally validated functional long noncoding RNAs (lncRNAs) and associated data for disease research.
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- Long noncoding RNAs (lncRNAs) play critical roles in biological processes and diseases.
- Functional characterization of lncRNAs is essential but remains challenging.
- The EVLncRNAs database provides a curated resource for experimentally validated functional lncRNAs.
Purpose of the Study:
- To update and expand the EVLncRNAs database with recent findings.
- To enhance the database with new data types and improved usability.
- To provide a comprehensive resource for lncRNA research.
Main Methods:
- Exhaustive manual curation of approximately 25,000 publications from May 2020 to May 2023.
- Incorporation of new data categories including functional classifications, interactions, structures, and COVID-19 related lncRNAs.
- Improvement of the web interface for enhanced browsing, visualization, and searching capabilities.
Main Results:
- A substantial increase in functional lncRNAs (154%) and associated diseases (160%).
- Significant growth in lncRNA-disease associations (186%), interactions (235%), and structures (138%).
- Notable expansion in circular RNAs (234%), resistant lncRNAs (235%), and exosomal lncRNAs (4724%).
Conclusions:
- EVLncRNAs 3.0 is the most extensive curated resource for experimentally validated functional lncRNAs.
- The updated database facilitates the exploration of novel lncRNA functions and their roles in diseases.
- The resource is freely available and will be invaluable for the scientific community.
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