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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Bone Remodeling and Repair01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Marrow Sampling and Transplants01:22

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Black Phosphorus Accelerates Bone Regeneration Based on Immunoregulation.

Minglong Qiu1, Nijiati Tulufu1, Guoqing Tang2

  • 1Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 12, 2023
PubMed
Summary
This summary is machine-generated.

Black phosphorus (BP) enhances bone regeneration by modulating the immune microenvironment. It promotes acute inflammation and anti-inflammatory factors, accelerating healing and tissue repair.

Keywords:
RNA sequencingblack phosphorusbone regenerationgene knocking-outimmunoregulation

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Regenerative Medicine

Background:

  • Precise regulation of inflammation is critical for effective bone regeneration.
  • Challenges exist in balancing acute inflammation with timely resolution to promote healing.
  • The interplay between the immune system and bone healing (osteoinmunity) is a key area of research.

Purpose of the Study:

  • To investigate the potential of black phosphorus (BP) in accelerating bone regeneration.
  • To elucidate the immunomodulatory mechanisms by which BP influences the bone healing process.
  • To explore BP's role in creating an osteogenic immunological microenvironment.

Main Methods:

  • Investigated the effect of black phosphorus on inflammatory responses in bone regeneration models.
  • Analyzed the secretion of pro-inflammatory and anti-inflammatory factors.
  • Examined the impact of BP on macrophage activation and interleukin 33 (IL-33) expression.
  • Assessed the effect of BP-mediated IL-33 on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).

Main Results:

  • Black phosphorus (BP) was found to accelerate bone regeneration by establishing an osteogenic immune microenvironment.
  • BP enhances acute inflammatory responses and promotes the secretion of anti-inflammatory factors, leading to faster inflammation resolution and tissue regeneration.
  • Mechanistically, BP stimulates macrophages to express IL-33, which amplifies early inflammation and promotes its regression, while also directly driving osteogenic differentiation of BMSCs.

Conclusions:

  • This study demonstrates that black phosphorus (BP) possesses immunomodulatory potential for enhancing bone regeneration.
  • BP effectively regulates both early inflammatory responses and later inflammation resolution, creating a favorable osteoimmune microenvironment.
  • The findings highlight BP as a promising biomaterial for clinical applications in bone repair by managing the immune microenvironment.