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Related Experiment Video

Updated: Jul 11, 2025

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Published on: October 24, 2012

Mapping the individual human cortex using multidimensional MRI and unsupervised learning.

Shinjini Kundu^1,2, Stephanie Barsoum³, Jeanelle Ariza⁴

¹Department of Radiology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.

Brain Communications

|November 13, 2023

Summary

This summary is machine-generated.

Researchers developed a new MRI technique to image human cortical layers, revealing layer-specific microstructural differences. This noninvasive method advances understanding of brain development and neurodevelopmental disorders.

Keywords:

cortical parcellation diffusion–relaxation machine learning microstructure imaging multidimensional MRI

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Last Updated: Jul 11, 2025

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

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Published on: June 14, 2010

Concurrent EEG and Functional MRI Recording and Integration Analysis for Dynamic Cortical Activity Imaging

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Published on: June 30, 2018

Area of Science:

Neuroimaging
Human Brain Anatomy
Machine Learning

Background:

Human cortical cytoarchitecture underpins cognitive abilities.
Cortical maldevelopment is linked to neurodevelopmental diseases.
Noninvasive imaging of cortical layers is currently unavailable.

Purpose of the Study:

To introduce a novel, noninvasive method for imaging human cortical lamina.
To address the gap in detailed cortical layer visualization.
To correlate microstructural features with cytoarchitecture.

Main Methods:

Combined diffusion-relaxation multidimensional MRI with unsupervised machine learning.
Developed an approach with enhanced microstructural sensitivity.
Validated the method using ex vivo MRI and postmortem Nissl staining.

Main Results:

Generated maps sensitive to areal differences in cytoarchitectonic features.
Revealed layer-specific diffusion-relaxation signatures.
Observed reductions in relaxation times and diffusivities at deeper cortical levels, suggesting myelin and cellular variations.

Conclusions:

The new MRI technique can visualize cortical layers and their microstructural variations.
Findings suggest radial decreases in myelin and changes in cell size/anisotropy.
This method offers potential for research in neurodevelopment and related disorders.