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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

689
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
689
Allergic Drug Reactions01:27

Allergic Drug Reactions

850
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
850
Allergic Reactions02:06

Allergic Reactions

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Overview
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Cross-reactivity00:42

Cross-reactivity

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Overview
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

339
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
339
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

144
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
144

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Related Experiment Video

Updated: Jul 11, 2025

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

2.8K

TMP-SMX induced type 4 hypersensitivity with multi-organ involvement.

Samantha Sircar1, Melanie Rayan1, Peters Okonoboh1

  • 1University of Central Florida College of Medicine, Graduate Medical Education / HCA Florida North Florida Hospital, Internal Medicine Residency Program, 6500 W Newberry Rd, Gainesville, FL 32605, United States.

Idcases
|November 13, 2023
PubMed
Summary
This summary is machine-generated.

Trimethoprim-sulfamethoxazole (TMP-SMX) can cause rare but severe multi-organ dysfunction, including rash, liver issues, and kidney injury. Early recognition and supportive care are crucial for managing these adverse drug reactions.

Area of Science:

  • Pharmacology
  • Internal Medicine
  • Toxicology

Background:

  • Trimethoprim-sulfamethoxazole (TMP-SMX) is a widely used antibiotic for various infections.
  • While generally safe, TMP-SMX can rarely cause severe adverse reactions like myelosuppression and hepatitis.
Keywords:
AntibioticsCritical careInfectious diseaseTMP-SMX

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